Muhammad Najib

Biography

Before returning to education, Muhammad had 3 years’ experience in metal injection moulding, where he manufactured small intricate shapes for military applications. He also worked as a director in MN Traders in Glasgow, from 2008-2014.

PhD: Dissolution of complex particulate-based products

In-vitro measurement of tablet dissolution is carried out routinely to guide development and assess batch-to-batch quality of oral solid dosage forms. However, understanding of the underlying process of single-particle dissolution remains largely empirical. The development of a dissolution model which is both accurate and mechanistic is highly desirable. Existing dissolution models generally assume that the particles are spherical with constant surface area and a singular, undifferentiated interface with the solution medium. These models largely fail to predict the dissolution rates of faceted crystals accurately as they do not incorporate face-specific factors such as diffusion coefficients, surface areas, specific intermolecular interactions and the effect of hydrodynamic environment. This research aims to incorporate face specific and hydrodynamic factors into the dissolution modelling to make it a better predictive tool.

Outreach, training and other activities:

• Placement with Pfizer (2 weeks, Apr 2018)
• Pfizer Cross CDT Day 18 Oct 2017

Publications and presentations:

Masters research project in year 1 of CDT:

• ‘Modelling breakage of needle crystals’ with Professor Andrew Bayly, Chemical & Process Engineering