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Bradley Tyson

Location
Level 1, Energy Building
Sponsor
Syngenta
Primary Supervisor
Dr Elena Simone, Food Science & Nutrition
Qualifications
MChem Chemistry, Lincoln

Biography

Bradley completed his Master’s in Chemistry at the University of Lincoln as the first graduating class of the course in 2018. During his final year, Bradley was on placement at Pfizer (Sandwich site). He also completed a number of industry sponsored projects whilst at university, as well as a summer project in catalysis. Bradley has geared his learning towards crystallography and computational modelling throughout his degree.

PhD: Crystallisation Modelling and Measurement for the Control of Crystal Size and Morphology in Chiral Systems

The crystallisation of chiral systems has always been a challenge when considering reliable product production. This work plans to investigate the effects of diastereomeric crystallisation of mixed systems of ribose sugars and their derivatives at different scales. With the focus towards sugars; liquid state transformations and their impact on solid state will be of great importance to accurately predict and measure product formation. The work entails the use of novel on line and off line analysis of the product. The end goal of the project is to build up a kinetic model that can be used to predict product formation and help to tailor reactions for subsequent product crystallisations.

Research Project(s) during degree:

  • Third year - Structured Project: The Creation and Analysis of Ternary Co-Crystal Systems - (supervised by Professor Ian Scowen and Dr Tasnim Munshi). Synthesis of 3 component metal-organic systems using PXRD and SCXRD for characterisation.
  • Final year - Industrial Project: Exploring Salt Disproportionation by Multidisciplinary Approaches (supervised by Professor Ian Scowen and Dr Tasnim Munshi of the University of Lincoln and Radoslav Penchev and Klimentina Pencheva of Pfizer). Applying computational modelling to assess salt disproportionation propensity, as well as synthesising and characterising salts, stability testing and monitoring using PXRD.

Industrial experience/placements:

  • Pfizer placement 2017-2018: Research within the Drug Product Design department at Pfizer, focused on salt disproportionation within pharmaceutical formulations. Applying computational modelling using a script written by Alexandru Moldovan (Leeds, CP3 Cohort#2) and Radoslav Penchev (Pfizer) to assess the propensity for salt disproportionation with a range of different excipients, with the end goal of ranking excipient suitability to the salt in question. Synthesis, characterisation and stability testing formed the experimental backbone of the placement, with computational modelling used to validate the experimental.
  • Summer placement - independent project: The Mechanistic Development of Cobalt Photoredox Catalysts. Applying computational modelling to assess suitability of ligands within photoredox catalysts, as well synthesising and characterising ligands and catalysts.

Outreach, training and other activities:

  • STEM Ambassador at Pfizer
  • Student Ambassador; University of Lincoln (Open days and Outreach programmes focused on inducting new and prospective students to the University, as well as running activities for A-Level students, members of the public and current University students)

Masters research project in year 1 of CDT:

  • ‘Chemical Pathways in the Synthesis of Surfactant-Stabilised Calcium Carbonate Nanoparticles’ with Professor Sven Schroeder, Chemical & Process Engineering