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Staff Profile

Frans Muller

Deputy Director and Professor of Chemical and Process Engineering

+44 (0) 113 343 0449 / +44 (0) 113 3432933
F.L.Muller@Leeds.ac.uk

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Professor Muller has had an extensive and distinguished industrial career, taking up a chair in Chemical Process Engineering in the School of Chemical and Process Engineering, and the School of Chemistry. His academic studies began in Holland in 1983 studying Chemical Engineering at Delft University of Technology, followed by a PhD at the University of Cambridge with Professor John F. Davidson and a postdoc at the University de Technology de Compiegne (Fr). In 1994 he joined Zeneca at Huddersfield (Later Syngenta) where he developed DynoChem, a dynamic simulation package now widely used across the pharmaceutical industry. In 2006 he moved to AstraZeneca helping to bring large-scale thinking to early development through the invention and application of scale-up risk evaluations (SURE) and work on the crystallisation workflow concept. He was involved in continuous processing initiatives in AstraZeneca culminating in project managing the AZ element of the F3 factory, a 30m euro pan-European project, before joining the University of Leeds in 2011.

There are three key themes to Professor Muller’s research interests:

  1. Phenomena
    Mixing, Multi Phase reactions, Unit Processes
    Nucleation, Solidification, Yields stress, Thixotropic fluids
    Flow Field Validation
  2. Modelling
    Mechanistic, Kinetics
    Thermodynamic
    CFD, LES for Flow, 3D Mechanistic
    Development and Scale up workflows and risk assessment
  3. Process Technology
    Flow Chemistry, Slow Flow Reactors
    Work up, Process driven scale-up, Plug and Produce

As the CDT’s Deputy Director, Professor Muller takes primary responsibility for the academic work of the CDT, which covers the following areas:

  • The development and delivery of the integrated MSc including the personal and professional development work, and its compliance with academic regulation at school, faculty, and institutional level;
  • The facilitation of the CDT PhD project allocation process;
  • The co-ordination of the CDT’s academic programme delivery team (module leaders, and core teaching staff);
  • The management of the CDT personnel, such as teaching fellows, and any academic-related posts such as teaching assistants or demonstrators.

Publications

Some of Professor Muller’s most recent Publications include;

Muller, F. L. (2013). Continuous-flow reactors for the rapid evolution and validation of kinetic motifs. Chimica Oggi-Chemistry Today,    33(4) 14.

Muller, F. L. (2013). How green is your engineering proposal? – Life cycle impact assessment in High Value Chemical Manufacturing. Chimica Oggi-Chemistry Today, 31(4), 34-39.

Singh, R., Rozada-Sanchez, R., Dean, W., Perkins, J., Muller, F., Godfrey, A., Gernaey, K. V., Gani, R., & Woodley, J. M. (2012). A generic process template for continuous pharmaceutical production. Computer Aided Chemical Engineering, 31, 715-719.

MS Abhishek, S Choudhari, F Muller (2012). Observations of solid–liquid systems in anchor agitated vessels. Chemical Engineering Research and Design 90 (6), 750-756.

MacLeod C., Muller F.L. (2012). On the Fracture of Pharmaceutical Needle-Shaped Crystals during Pressure Filtration: Case Studies and Mechanistic Understanding. Organic Process Research & Development 16 (3), 425-434.

Muller F.L. Fielding M., Black S.N. (2009). A Practical Approach for Using Solubility to Design Cooling Crystallisations. Organic Process Research & Development, 13, 1315–1321.

Muller F.L. (2009) On the rheological behaviour of Batch crystallisations. Chemical Engineering Research and Design 87, 627-632.

Muller F.L., Latimer J.M. (2009). Anticipation of scale up issues in pharmaceutical development. Computers and Chemical Engineering 33, 1051-1055.

Muller F.L. (1996). DynoChem – detailed case study: scale up of a 4 phase hydrogenation. Symp. Pap. – Inst. Chem. Eng., North West. Branch (5, Batch Processing III), 4/1-4/6

Muller F.L., J.P. Pain, P. Villon (1993). Modèle d’ecoulement dans un tube vertical soumis a un chauffage ohmique direct. Acte Colloque de la Société Française des Thermiciens (SFT), Ed. Europ. Therm. & Indust., Paris.

Muller F.L., J.F. Davidson (1992). On the contribution of small bubbles to mass transfer in bubble columns containing highly viscous liquids. The First International Conference on Gas-Liquid and Gas-Solid-Liquid Reactor Engineering, Columbus, Ohio, Chem. Eng. Sci. 47, 3525.

A link to Professor Muller’s Google Scholar Page Can be found here.